Acknowledgements

Researchers using ACC equipment or services agree to acknowledge the support of "The Analytical Chemistry Core at Harvard Medical School" in publications arising from use of the facility. If an ACC staff member has made an important intellectual contribution to the project, as determined by generally accepted criteria for academic collaborations, then the staff member should be considered for authorship. 

Publications Supported by the ACC

Mychack, A., Evans, D., Gilles, T., James, M. J., & Walker, S. (2025). Staphylococcus aureus uses a GGDEF protein to recruit diacylglycerol kinase to the membrane for lipid recycling. Proceedings of the National Academy of Sciences of the United States of America, 122(12), e2414696122. https://doi.org/10.1073/pnas.2414696122

Gründling, A., Brogan, A. P., James, M. J., Ramirez-Guadiana, F. H., Roney, I. J., Bernhardt, T. G., & Rudner, D. Z. (2025). PgpP is a broadly conserved phosphatase required for phosphatidylglycerol lipid synthesis. Proceedings of the National Academy of Sciences of the United States of America, 122(5), e2418775122. https://doi.org/10.1073/pnas.2418775122

Glick, V. J., Webber, C. A., Simmons, L. E., Martin, M. C., Ahmad, M., Kim, C. H., Adams, A. N. D., Bang, S., Chao, M. C., Howard, N. C., Fortune, S. M., Verma, M., Jost, M., Beura, L. K., James, M. J., Lee, S. Y., Mitchell, C. M., Clardy, J., Kim, K. H., & Gopinath, S. (2024). Vaginal lactobacilli produce anti-inflammatory β-carboline compounds. Cell host & microbe, 32(11), 1897–1909.e7. https://doi.org/10.1016/j.chom.2024.09.014

Publications Authored by ACC Staff

Sudo, K., Delmas-Eliason, A., Soucy, S., Barrack, K. E., Liu, J., Balasubramanian, A., Shu, C. J., James, M. J., Hegner, C. L., Dionne, H. D., Rodriguez-Palacios, A., Krause, H. M., O'Toole, G. A., Karpen, S. J., Dawson, P. A., Schultz, D., & Sundrud, M. S. (2024). Quantifying Forms and Functions of Enterohepatic Bile Acid Pools in Mice. Cellular and molecular gastroenterology and hepatology, 18(6), 101392. https://doi.org/10.1016/j.jcmgh.2024.101392

Perreault, M., Means, J., Gerson, E., James, M., Cotton, S., Bergeron, C. G., Simon, M., Carlin, D. A., Schmidt, N., Moore, T. C., Blasbalg, J., Sondheimer, N., Ndugga-Kabuye, K., Denney, W. S., Isabella, V. M., Lubkowicz, D., Brennan, A., & Hava, D. L. (2024). The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers. Cell host & microbe, 32(3), 382–395.e10. https://doi.org/10.1016/j.chom.2024.01.005

Kalantari, A., James, M. J., Renaud, L. A., Perreault, M., Monahan, C. E., McDonald, M. N., Hava, D. L., & Isabella, V. M. (2023). Robust performance of a live bacterial therapeutic chassis lacking the colibactin gene cluster. PloS one, 18(2), e0280499. https://doi.org/10.1371/journal.pone.0280499

Lubkowicz, D., Horvath, N. G., James, M. J., Cantarella, P., Renaud, L., Bergeron, C. G., Shmueli, R. B., Anderson, C., Gao, J. R., Kurtz, C. B., Perreault, M., Charbonneau, M. R., Isabella, V. M., & Hava, D. L. (2022). An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria. Molecular systems biology, 18(3), e10539. https://doi.org/10.15252/msb.202110539

Canale, F. P., Basso, C., Antonini, G., Perotti, M., Li, N., Sokolovska, A., Neumann, J., James, M. J., Geiger, S., Jin, W., Theurillat, J. P., West, K. A., Leventhal, D. S., Lora, J. M., Sallusto, F., & Geiger, R. (2021). Metabolic modulation of tumours with engineered bacteria for immunotherapy. Nature, 598(7882), 662–666. https://doi.org/10.1038/s41586-021-04003-2

Leventhal, D. S., Sokolovska, A., Li, N., Plescia, C., Kolodziej, S. A., Gallant, C. W., Christmas, R., Gao, J. R., James, M. J., Abin-Fuentes, A., Momin, M., Bergeron, C., Fisher, A., Miller, P. F., West, K. A., & Lora, J. M. (2020). Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity. Nature communications, 11(1), 2739. https://doi.org/10.1038/s41467-020-16602-0

Oukoloff, K., Nzou, G., Varricchio, C., Lucero, B., Alle, T., Kovalevich, J., Monti, L., Cornec, A. S., Yao, Y., James, M. J., Trojanowski, J. Q., Lee, V. M., Smith, A. B., 3rd, Brancale, A., Brunden, K. R., & Ballatore, C. (2021). Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-a]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies. Journal of medicinal chemistry, 64(2), 1073–1102. https://doi.org/10.1021/acs.jmedchem.0c01605

Henderson, M. X., Covell, D. J., Chung, C. H., Pitkin, R. M., Sandler, R. M., Decker, S. C., Riddle, D. M., Zhang, B., Gathagan, R. J., James, M. J., Trojanowski, J. Q., Brunden, K. R., Lee, V. M. Y., & Luk, K. C. (2020). Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease. Neurobiology of disease, 136, 104712. https://doi.org/10.1016/j.nbd.2019.104712

Zhang, B., Yao, Y., Cornec, A. S., Oukoloff, K., James, M. J., Koivula, P., Trojanowski, J. Q., Smith, A. B., 3rd, Lee, V. M., Ballatore, C., & Brunden, K. R. (2018). A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model. Molecular neurodegeneration, 13(1), 59. https://doi.org/10.1186/s13024-018-0291-3

Oukoloff, K., Kovalevich, J., Cornec, A. S., Yao, Y., Owyang, Z. A., James, M., Trojanowski, J. Q., Lee, V. M., Smith, A. B., 3rd, Brunden, K. R., & Ballatore, C. (2018). Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines. Bioorganic & medicinal chemistry letters, 28(12), 2180–2183. https://doi.org/10.1016/j.bmcl.2018.05.010

Lassalas, P., Oukoloff, K., Makani, V., James, M., Tran, V., Yao, Y., Huang, L., Vijayendran, K., Monti, L., Trojanowski, J. Q., Lee, V. M., Kozlowski, M. C., Smith, A. B., 3rd, Brunden, K. R., & Ballatore, C. (2017). Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group. ACS medicinal chemistry letters, 8(8), 864–868. https://doi.org/10.1021/acsmedchemlett.7b00212

Cornec, A. S., Monti, L., Kovalevich, J., Makani, V., James, M. J., Vijayendran, K. G., Oukoloff, K., Yao, Y., Lee, V. M., Trojanowski, J. Q., Smith, A. B., 3rd, Brunden, K. R., & Ballatore, C. (2017). Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases. Journal of medicinal chemistry, 60(12), 5120–5145. https://doi.org/10.1021/acs.jmedchem.7b00475

Kovalevich, J., Cornec, A. S., Yao, Y., James, M., Crowe, A., Lee, V. M., Trojanowski, J. Q., Smith, A. B., 3rd, Ballatore, C., & Brunden, K. R. (2016). Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies. The Journal of pharmacology and experimental therapeutics, 357(2), 432–450. https://doi.org/10.1124/jpet.115.231175

Lassalas, P., Gay, B., Lasfargeas, C., James, M. J., Tran, V., Vijayendran, K. G., Brunden, K. R., Kozlowski, M. C., Thomas, C. J., Smith, A. B., 3rd, Huryn, D. M., & Ballatore, C. (2016). Structure Property Relationships of Carboxylic Acid Isosteres. Journal of medicinal chemistry, 59(7), 3183–3203. https://doi.org/10.1021/acs.jmedchem.5b01963

Herbst-Robinson, K. J., Liu, L., James, M., Yao, Y., Xie, S. X., & Brunden, K. R. (2015). Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors. Scientific reports, 5, 18286. https://doi.org/10.1038/srep18286

Cornec, A. S., James, M. J., Kovalevich, J., Trojanowski, J. Q., Lee, V. M., Smith, A. B., 3rd, Ballatore, C., & Brunden, K. R. (2015). Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine. Bioorganic & medicinal chemistry letters, 25(21), 4980–4982. https://doi.org/10.1016/j.bmcl.2015.03.002

Wang, X., Liu, L., Huang, L., Herbst-Robinson, K., Cornec, A. S., James, M. J., Sugiyama, S., Bassetto, M., Brancale, A., Trojanowski, J. Q., Lee, V. M., Smith, A. B., 3rd, Brunden, K. R., & Ballatore, C. (2014). Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS medicinal chemistry letters, 5(9), 1015–1020. https://doi.org/10.1021/ml5002085

Ballatore, C., Gay, B., Huang, L., Robinson, K. H., James, M. J., Trojanowski, J. Q., Lee, V. M., Brunden, K. R., & Smith, A. B., 3rd (2014). Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group. Bioorganic & medicinal chemistry letters, 24(17), 4171–4175. https://doi.org/10.1016/j.bmcl.2014.07.047

Lou, K., Yao, Y., Hoye, A. T., James, M. J., Cornec, A. S., Hyde, E., Gay, B., Lee, V. M., Trojanowski, J. Q., Smith, A. B., 3rd, Brunden, K. R., & Ballatore, C. (2014). Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies. Journal of medicinal chemistry, 57(14), 6116–6127. https://doi.org/10.1021/jm5005623

Brunden, K. R., Gardner, N. M., James, M. J., Yao, Y., Trojanowski, J. Q., Lee, V. M., Paterson, I., Ballatore, C., & Smith, A. B., 3rd (2013). MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. ACS medicinal chemistry letters, 4(9), 886–889. https://doi.org/10.1021/ml400233e

Crowe, A., James, M. J., Lee, V. M., Smith, A. B., 3rd, Trojanowski, J. Q., Ballatore, C., & Brunden, K. R. (2013). Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation. The Journal of biological chemistry, 288(16), 11024–11037. https://doi.org/10.1074/jbc.M112.436006

Soper, J. H., Sugiyama, S., Herbst-Robinson, K., James, M. J., Wang, X., Trojanowski, J. Q., Smith, A. B., 3rd, Lee, V. M., Ballatore, C., & Brunden, K. R. (2012). Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease. ACS chemical neuroscience, 3(11), 928–940. https://doi.org/10.1021/cn3000795

Ballatore, C., Crowe, A., Piscitelli, F., James, M., Lou, K., Rossidivito, G., Yao, Y., Trojanowski, J. Q., Lee, V. M., Brunden, K. R., & Smith, A. B., 3rd (2012). Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties. Bioorganic & medicinal chemistry, 20(14), 4451–4461. https://doi.org/10.1016/j.bmc.2012.05.027

Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., Brunden, K. R., Wilson, D. A., & Landreth, G. E. (2012). ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science (New York, N.Y.), 335(6075), 1503–1506. https://doi.org/10.1126/science.1217697

Carroll, J. C., Iba, M., Bangasser, D. A., Valentino, R. J., James, M. J., Brunden, K. R., Lee, V. M., & Trojanowski, J. Q. (2011). Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(40), 14436–14449. https://doi.org/10.1523/JNEUROSCI.3836-11.2011

Ballatore, C., Soper, J. H., Piscitelli, F., James, M., Huang, L., Atasoylu, O., Huryn, D. M., Trojanowski, J. Q., Lee, V. M., Brunden, K. R., & Smith, A. B. (2011). Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists. Journal of medicinal chemistry, 54(19), 6969–6983. https://doi.org/10.1021/jm200980u

Brunden, K. R., Yao, Y., Potuzak, J. S., Ferrer, N. I., Ballatore, C., James, M. J., Hogan, A. M., Trojanowski, J. Q., Smith, A. B., 3rd, & Lee, V. M. (2011). The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. Pharmacological research, 63(4), 341–351. https://doi.org/10.1016/j.phrs.2010.12.002

Brunden, K. R., Zhang, B., Carroll, J., Yao, Y., Potuzak, J. S., Hogan, A. M., Iba, M., James, M. J., Xie, S. X., Ballatore, C., Smith, A. B., 3rd, Lee, V. M., & Trojanowski, J. Q. (2010). Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(41), 13861–13866. https://doi.org/10.1523/JNEUROSCI.3059-10.2010

Ballatore, C., Brunden, K. R., Piscitelli, F., James, M. J., Crowe, A., Yao, Y., Hyde, E., Trojanowski, J. Q., Lee, V. M., & Smith, A. B., 3rd (2010). Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation. Journal of medicinal chemistry, 53(9), 3739–3747. https://doi.org/10.1021/jm100138f